Helv Paediat Acta. Turner syndrome 45,X. Help Community portal Recent changes Upload file. Academic Press.
The effects on physical and mental development increase with the number of extra Xs, and each extra X is associated with an IQ decrease of approximately 15—16 points, with language most affected, particularly expressive skills [ 10 ]. Most men with Klinefelter syndrome produce little or no sperm, but assisted reproductive procedures may make it possible for some men with Klinefelter syndrome to father children.
The syndrome was named after American endocrinologist Harry Klinefelterwho in worked with Fuller Albright and E. Arch Dis Child.
Most boys and men with Klinefelter syndrome will not be significantly affected and can live normal, healthy lives. Testosterone is the hormone that directs male sexual development before birth and during puberty. European Journal of Medical Genetics.
Thus it is a trisomy condition in which the person has 47 chromosomes in the nucleus instead of a normal number of The male is tall having long limbs.
Sex Dev. The likelihood of X chromosome nondisjunction increases with advancing maternal age. The recurrence risk is not increased above that of the general population. Small testicular size is the only consistent physical feature in 47,XXY. Klinefelter syndrome can also occur in other animals.
This change in the egg or sperm seems to happen randomly.